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Anesthesia for the Experimental Rats
실험용 쥐의 마취
JKSM 2013 May;22(1):1-6
Published online May 31, 2013
Copyright © 2013 The Korean Society for Microsurgery.

Hee-Rack Choi*,†, Jong-Hyun Ko*,†, Hae Beom Lee, Jun-Mo Lee*,†
최희락*,†, 고종현*,†, 이해범, 이준모*,†

*Department of Orthopedic Surgery, Chonbuk National University Medical School, Biomedical Research Institute, Chonbuk National University Hospital,College of Veterinary Medicine, Chonbuk National University, Jeonju, Kore
*전북대학교 의학전문대학원 정형외과학교실, 전북대학교병원 의생명연구원, 전북대학교 수의과대학
Received March 2, 2013; Accepted March 4, 2013.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
  Rats and mice are commonly used in experimental laboratories and anesthetic drugs are important for researchers to understand the details. Administration of fluids helps to stabilize the experimental animals before anesthesia via intravenously through the lateral vein in rats and in case of difficulty in catheterization and maintenance, fluids are usually administered as boluses. Large volumes of cool fluids will rapidly lead to hypothermia and all parenteral fluids must be warmed to body temperature before administration. Premedication with a sedative may ease induction with volatile anesthetic drugs. The first choice for rodent anesthesia is complete inhalational anesthesia. The second option is using injectable anesthesia. Recovery from the volatile agents that have been used rapid when the agent is no longer administered. Anesthetic monitoring equipment is an infant-size bell sthethoscope that can be used to ausculate the heart and lungs. Supplemental heating should be provided to reduce the heat loss supply and maintain core body temperature. The kinds of drugs, characteristics, route of administration and care after surgery were reviewed and summarized from the references. Anesthetic drugs, maintenance, monitoring and aftercare are important in the laboratories to keep the animal safe in all experimental procedures.
Keywords : Anethetics, Rats, Mice
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